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Year Number of Results
2004 4
2005 18
2006 29
2007 53
2008 71
2009 75
2010 89
2011 90
2012 109
2013 130
2014 109
2015 113
2016 102
2017 76
2018 88
2019 92
2020 73
2021 89
2022 60
2023 69
2024 18

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1,379 results

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Page 1
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Cai W, Hu M, Li C, Wu R, Lu D, Xie C, Zhang W, Li T, Shen S, Huang H, Qiu W, Liu Q, Lu Y, Lu Z. Cai W, et al. Autophagy. 2023 Apr;19(4):1144-1163. doi: 10.1080/15548627.2022.2116833. Epub 2022 Sep 28. Autophagy. 2023. PMID: 36170234 Free PMC article.
FOXP3 ablation in macrophages results in detrimental stroke outcomes, emphasizing the beneficial role of FOXP3+ macrophages. ...With scRNAseq and analysis of FOXP3-bound-DNA isolated with CUT & RUN, we show that FOXP3 facilitates macrophage phagocy …
FOXP3 ablation in macrophages results in detrimental stroke outcomes, emphasizing the beneficial role of FOXP3+ macrophages. . …
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery.
Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A. Ito M, et al. Nature. 2019 Jan;565(7738):246-250. doi: 10.1038/s41586-018-0824-5. Epub 2019 Jan 2. Nature. 2019. PMID: 30602786
In addition to maintaining immune tolerance, FOXP3(+) regulatory T (T(reg)) cells perform specialized functions in tissue homeostasis and remodelling(1,2). ...Although brain T(reg) cells are similar to T(reg) cells in other tissues such as visceral adipose tissue and muscl …
In addition to maintaining immune tolerance, FOXP3(+) regulatory T (T(reg)) cells perform specialized functions in tissue homeostasis …
Mitochondrial-regulated Tregs: potential therapeutic targets for autoimmune diseases of the central nervous system.
Han A, Peng T, Xie Y, Zhang W, Sun W, Xie Y, Ma Y, Wang C, Xie N. Han A, et al. Front Immunol. 2023 Dec 12;14:1301074. doi: 10.3389/fimmu.2023.1301074. eCollection 2023. Front Immunol. 2023. PMID: 38149252 Free PMC article. Review.
Mitochondria, as the energy factories of cells, are essential for regulating the survival, differentiation, and function of Tregs. Studies have shown that patients with autoimmune diseases of the central nervous system, such as multiple sclerosis, neuromyelit …
Mitochondria, as the energy factories of cells, are essential for regulating the survival, differentiation, and function of Tregs. Studies h …
Adoptive therapy with amyloid-β specific regulatory T cells alleviates Alzheimer's disease.
Yang H, Park SY, Baek H, Lee C, Chung G, Liu X, Lee JH, Kim B, Kwon M, Choi H, Kim HJ, Kim JY, Kim Y, Lee YS, Lee G, Kim SK, Kim JS, Chang YT, Jung WS, Kim KH, Bae H. Yang H, et al. Theranostics. 2022 Nov 7;12(18):7668-7680. doi: 10.7150/thno.75965. eCollection 2022. Theranostics. 2022. PMID: 36451854 Free PMC article.
The present study aimed to define the therapeutic impact of a specific subpopulation of T cells that can suppress excessive inflammation in various immune and inflammatory disorders, namely, CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). Methods: To generate Abeta antig …
The present study aimed to define the therapeutic impact of a specific subpopulation of T cells that can suppress excessive inflammation in …
Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination.
Wang Y, Sadike D, Huang B, Li P, Wu Q, Jiang N, Fang Y, Song G, Xu L, Wang W, Xie M. Wang Y, et al. J Neuroinflammation. 2023 Feb 18;20(1):41. doi: 10.1186/s12974-023-02721-0. J Neuroinflammation. 2023. PMID: 36803990 Free PMC article.
Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated with neuroinflammation. Pyroptosis is a form of pro-inflammatory and lytic cell death which has been observed in CNS diseases recently. Regulatory T cells (Tregs …
Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated with neuroinflammation. Pyro …
Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.
Cekanaviciute E, Yoo BB, Runia TF, Debelius JW, Singh S, Nelson CA, Kanner R, Bencosme Y, Lee YK, Hauser SL, Crabtree-Hartman E, Sand IK, Gacias M, Zhu Y, Casaccia P, Cree BAC, Knight R, Mazmanian SK, Baranzini SE. Cekanaviciute E, et al. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10713-10718. doi: 10.1073/pnas.1711235114. Epub 2017 Sep 11. Proc Natl Acad Sci U S A. 2017. PMID: 28893978 Free PMC article.
In contrast, Parabacteroides distasonis, which was reduced in MS patients, stimulated antiinflammatory IL-10-expressing human CD4(+)CD25(+) T cells and IL-10(+)FoxP3(+) Tregs in mice. Finally, microbiota transplants from MS patients into germ-free mice resulted in more sev …
In contrast, Parabacteroides distasonis, which was reduced in MS patients, stimulated antiinflammatory IL-10-expressing human CD4(+)CD25(+) …
T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression.
Yazdani S, Seitz C, Cui C, Lovik A, Pan L, Piehl F, Pawitan Y, Kläppe U, Press R, Samuelsson K, Yin L, Vu TN, Joly AL, Westerberg LS, Evertsson B, Ingre C, Andersson J, Fang F. Yazdani S, et al. Nat Commun. 2022 Nov 8;13(1):6733. doi: 10.1038/s41467-022-34526-9. Nat Commun. 2022. PMID: 36347843 Free PMC article.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood. Here w …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central …
The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma.
Cho H, Kim SH, Kim SJ, Chang JH, Yang WI, Suh CO, Cheong JW, Kim YR, Lee JY, Jang JE, Kim Y, Min YH, Kim JS. Cho H, et al. Ann Hematol. 2017 Jul;96(7):1163-1173. doi: 10.1007/s00277-017-3014-x. Epub 2017 May 15. Ann Hematol. 2017. PMID: 28508176
The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, we examined the prognostic significance of CD68 and FoxP3 expression in tumor samples of 76 newly diagnosed immunocompetent PCNSL pat …
The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, …
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Bettelli E, et al. Nature. 2006 May 11;441(7090):235-8. doi: 10.1038/nature04753. Epub 2006 Apr 30. Nature. 2006. PMID: 16648838
Here we show, using mice with a reporter introduced into the endogenous Foxp3 locus, that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ T(reg) cells induced by TGF-beta. ...Our data demonstrate a dichotomy in …
Here we show, using mice with a reporter introduced into the endogenous Foxp3 locus, that IL-6, an acute phase protein induced during …
Regulatory T lymphocytes as a therapy for ischemic stroke.
Wang M, Thomson AW, Yu F, Hazra R, Junagade A, Hu X. Wang M, et al. Semin Immunopathol. 2023 May;45(3):329-346. doi: 10.1007/s00281-022-00975-z. Epub 2022 Dec 5. Semin Immunopathol. 2023. PMID: 36469056 Review.
Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells play important immunosuppressive roles to curtail inflammatory responses and regain immune homeostasis afte …
Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4(+)CD25(+)Foxp3 …
1,379 results